Over 100 million Americans suffer from chronic pain, which causes more disability than any other medical condition in the United States at a cost of $560–$635 billion per year. Opioid analgesics are frequently used to treat CP. However, long term use of opioids can cause brain changes such as opioid-induced hyperalgesia that, over time, increase pain sensation. Also, opioids fail to treat complex psychological factors that worsen pain-related disability, including beliefs about and emotional responses to pain. Cognitive behavioral therapy can (...) be efficacious for CP. However, CBT generally does not focus on important factors needed for long-term functional improvement, including attainment of personal goals and the psychological flexibility to choose responses to pain. Acceptance and Commitment Therapy has been recognized as an effective, non-pharmacologic treatment for a variety of CP conditions. However, little is known about the neurologic mechanisms underlying ACT. We conducted an ACT intervention in women with chronic musculoskeletal pain. Functional magnetic resonance imaging data were collected pre- and post-ACT, and changes in functional connectivity were measured using Network-Based Statistics. Behavioral outcomes were measured using validated assessments such as the Acceptance and Action Questionnaire, the Chronic Pain Acceptance Questionnaire, the Center for Epidemiologic Studies Depression Scale, and the NIH Toolbox Neuro-QoLTM scales. Results suggest that, following the 4-week ACT intervention, participants exhibited reductions in brain activation within and between key networks including self-reflection, emotion, and cognitive control. These changes in connectivity strength were correlated with changes in behavioral outcomes including decreased depression and pain interference, and increased participation in social roles. This study is one of the first to demonstrate that improved function across the DMN, SN, and FPN may drive the positive outcomes associated with ACT. This study contributes to the emerging evidence supporting the use of neurophysiological indices to characterize treatment effects of alternative and complementary mind-body therapies. (shrink)

Neural substrates of fatigue in traumatic brain injury are not well understood despite the considerable burden of fatigue on return to productivity. Fatigue is associated with diminishing performance under conditions of high cognitive demand, sense of effort, or need for motivation, all of which are associated with cognitive control brain network integrity. We hypothesize that the pathophysiology of TBI results in damage to diffuse cognitive control networks, disrupting coordination of moment-to-moment monitoring, prediction, and regulation of behavior. We investigate the cingulo-opercular (...) and frontoparietal networks, which are engaged to sustain attention for task and maintain performance. A total of 61 individuals with mild TBI and 42 orthopedic control subjects participated in functional MRI during performance of a constant effort task requiring altering the amount of effort utilized to manually squeeze a pneumostatic bulb across six 30-s trials. Network-based statistics assessed within-network organization and fluctuation with task manipulations by group. Results demonstrate small group differences in network organization, but considerable group differences in the evolution of task-related modulation of connectivity. The mild TBI group demonstrated elevated CO connectivity throughout the task with little variation in effort level or time on task, while CO connectivity diminished over time in controls. Several interregional CO connections were predictive of fatigue in the TBI group. In contrast, FP connectivity fluctuated with task manipulations and predicted fatigue in the controls, but connectivity fluctuations were delayed in the mild traumatic brain injury group and did not relate to fatigue. Thus, the mTBI group’s hyper-connectivity of the CO irrespective of task demands, along with hypo-connectivity and delayed peak connectivity of the FP, may allow for attainment of task goals, but also contributes to fatigue. Findings are discussed in relation to performance monitoring of prediction error that relies on internal cues from sensorimotor feedback during task performance. Delay or inability to detect and respond to prediction errors in TBI, particularly evident in bilateral insula-temporal CO connectivity, corresponds to day-to-day fatigue and fatigue during task performance. (shrink)

In this thorough compendium, nineteen accomplished scholars explore, in some manner the values they find inherent in the world, their nature, and revelence through the thought of Frederick Ferré. These essays, informed by the insights of Ferré and coming from manifold perspectives—ethics, philosophy, theology, and environmental studies, advance an ambitious challenge to current intellectual and scholarly fashions.

In this thorough compendium, nineteen accomplished scholars explore, in some manner the values they find inherent in the world, their nature, and revelence through the thought of Frederick FerrZ. These essays, informed by the insights of FerrZ and coming from manifold perspectives—ethics, philosophy, theology, and environmental studies, advance an ambitious challenge to current intellectual and scholarly fashions.

This paper concerns a key point of decision in Donald Davidson's early work in philosophy of language — a fateful decision that set him and the discourse in the area on the path of truth-theoretic semantics. The decision of moment is the one Davidson makes when, in the face of a certain barrier, he gives up on the idea of constructing an explicit meaning theory that would parallel Tarski's recursive way with truth theory. For Davidson there was little choice: (...) he tells us he does not see how to deal with the difficulty except in the radical way he proposes. But there is a way to give such a meaning theory — a meaning theory proper which, using classical logic only, meets a meaning-theoretic analogue of Convention T, satisfies Davidson’s three key desiderata for a theory of meaning, reflects linguistic competence, and avoids quantifying over meanings. The meaning theory sketched here uses Tarskian strategies, as Davidson proposed, but differs from Davidson's approach in not going by way of a truth theory for the target language. (shrink)

The Einsteinian revolution, which began around 1905, was one of the most remarkable in the history of physics. It replaced Newtonian mechanics, which had been accepted as completely correct for nearly 200 years, by the special and general theories of relativity. It also eliminated the aether, which had dominated physics throughout the nineteenth century. This paper poses the question of why this momentous scientific revolution began. The suggested answer is in terms of the remarkable series of discoveries and inventions which (...) occurred in the preceding decade and which were the result of technological developments in instrumentation. The paper gives a survey of these inventions and discoveries, which include X-rays, radioactivity, the electron, wireless transmissions across the Atlantic and the patenting of the first thermionic valve. An attempt is then made to show that it was these developments, which gave rise to special relativity. (shrink)

THE MIND-BODY PROBLEM: A GUIDE TO THE CURRENT DEBATE (EDITED BY RICHARD WARNER AND TA D E U S Z SZUBKA) contains recent essays by the key players in the the field of the Mind-Body problem: Searle, Fodor, Problem Honderich, Nagel, McGinn, Stich, Rorty and others. But there are a few interesting exceptions, for example Edelman, Popper, Putnam and Dennett. Nevertheless, these thinkers do get a mention here and there, and nearly all the exciting topical issues are dealt with, including (...) externalism, functionalism, intentionality, Turing computational models, and the relationship between these philosophical problems and psychology. I am particularly struck by the tendency to engage in an evasive stratagem when it comes to stating the physicalist thesis. Instead of a clear definitive position about what kind of physical science would achieve the hoped-for reduction, what I found was variations on Lewis's claim that the reduction would be effected by a "unified body of scientific theories of the sort we now accept". Materialism used to be a clear doctrine: a clockwork Universe of impenetrable particles. But materialism transcended itself. First through Hobbes' and Leibniz's criticisms of Descartes, then Newton's demolition of the Cartesian idea that matter was essentially extension by introducing gravity (action at a distance) and then through the field theories of Faraday and Maxwell, and more recently through Einstein's work, which undermined the "substance" view of matter, something that remained permanent while other changes occurred. I contrast the perspectives of the Churchlands with those of Donald T. Campbell, Karl Popper and other evolutionary and emergentist views. -/- . (shrink)

Greg Ray (2014) believes he has discovered a crucial oversight in Donald Davidson’s semantic programme, recognition of which paves the way for a novel approach to Davidsonian semantics. We disagree: Ray’s novel approach involves a tacit appeal to pre-existing semantic knowledge which vitiates its interest as a development of the Davidsonian programme.

Acts of violence and murder have historically proved difficult to accommodate in standard accounts of the formula of universal law (FUL) version of Kant’s Categorical Imperative (CI). In “Murder and Mayhem,” Barbara Herman offers a distinctive account of the status of these acts that is intended to be appropriately didactic in comparison to accounts like the practical contradiction model. I argue that while Herman’s account is a promising one, the distinction she makes between coercive and non-coercive violence and her response (...) to concerns with the classification of the latter as imperfect duties raise significant questions about the status of some duties. I suggest that we look, instead, to Kant’s treatment of suicide in The Metaphysics of Morals for an account of norms of non-violence and, in particular, to the connection between this duty and concerns with inner freedom and moral health. I argue that we can use this account to inform our general understanding of duties prohibiting killing and violence, and that the resulting account is a promising one. (shrink)

The almost 300 articles contain not only historical accounts but also some indication of the state of present day study in classical philosophy.

Presenting a landmark in linguistics and cognitive science, Ray Jackendoff proposes a new holistic theory of the relation between the sounds, structure, and meaning of language and their relation to mind and brain. Foundations of Language exhibits the most fundamental new thinking in linguistics since Noam Chomsky's Aspects of the Theory of Syntax in 1965—yet is readable, stylish, and accessible to a wide readership. Along the way it provides new insights on the evolution of language, thought, and communication.

A study of the contribution semantics makes to the syntactic patterns of English: an intepretive theory of grammar.

There is a familiar problem in moral theories that recognize positive obligations to help others related to the practical room these obligations leave for ordinary life, and the risk that open-ended obligations to help others will consume our lives and resources. Responding to this problem, Kantians have tended to emphasize the idea of limits on positive obligations but are typically unsatisfactorily vague about the nature and extent of these limits. I argue here that aspects of Kant’s discussion of duties of (...) virtue owed to ourselves suggest a useful metric we can use in discussing these limits and that generalizing this account and combining it with elements of Barbara Herman’s view, offers us an attractive model of moral deliberation with the resources we need to engage the critic’s challenge properly. (shrink)

Lack of vaccine confidence can contribute to drops in vaccination coverage and subsequent outbreaks of diseases like measles and polio. Low trust in vaccines is attributed to a combination of factors, including lack of understanding, vaccine scares, flawed policies, social media and mistrust of vaccine manufacturers, scientists and decision-makers. The COVID-19 crisis has laid bare societies’ vulnerability to new pathogens and the critical role of vaccines in containing this and future pandemics. It has also put science at the forefront of (...) the response, with several governments relying on academics to help shape policy and communicate with the public. Against this backdrop, protecting public trust in scientists and scientific output is arguably more important than ever. Yet, conflicts of interest in biomedical research remain ubiquitous and harmful, and measures to curb them have had limited success. There is also evidence of bias in industry-sponsored vaccine studies and academics are voicing concerns about the risks of working in a CoI prevalent research area. Here, we set out to challenge established thinking with regard to vaccine confidence, by shifting the gaze from a deficit in public understanding towards probity in research relationships and suggesting an alternative and perhaps complementary strategy for addressing vaccine mistrust. We argue that a concerted effort needs to be made to revisit the norms that undergird contemporary vaccine research, coupled with a willingness of all stakeholders to reimagine those relationships with an emphasis on demonstrating trustworthiness and probity. (shrink)

Immanuel Kant was a German philosopher. He is a central figure of modern philosophy, and set the terms by which all subsequent thinkers have had to grapple. He argued that human perception structures natural laws, and that reason is the source of morality. His thought continues to hold a major influence in contemporary thought, especially in fields such as metaphysics, epistemology, ethics, political philosophy, and aesthetics.

The early essays in this volume proceed on the assumption that a compatability system can be fashioned that will not only bring religious knowledge claims into harmony with scientific claims, but will also show there to be a fundamental similarity of method in religious and scientific thinking. They are not, however, unambiguously successful. Consequently Wiebe sets out in the succeeding essays to seek an understanding of the religion/science relationship that does not assume they must be compatible. The examination, in the (...) final analysis, reveals a fundamental contradiction in the compatability system building programme which suggests that religious belief is beyond legitimation. (shrink)

Ludwig Wittgenstein is perhaps the greatest philosopher of the twentieth century, and certainly one of the most original in the entire Western tradition. Given the inaccessibility of his work, it is remarkable that he has inspired poems, paintings, films, musical compositions, titles of books -- and even novels. In his splendid biography, Ray Monk has made this very compelling human being come alive in a way that perfectly explains the fascination he has evoked. Wittgenstein's life was one of great moral (...) and spiritual depth. Although his work addresses problems of logic, language, mind, and knowledge, he often described it as having an ethical point, and once said that he "could not help seeing every problem from a religious point of view." In successfully bridging the gap assumed by many to exist between Wittgenstein's life and his work, Monk's biography helps to explain the interest in Wittgenstein's later philosophy on the part of Buddhist scholars. (shrink)

BackgroundThe Supreme Court of Canada removed the prohibition on physicians assisting in patients dying on 6 February 2015. Bill C-14, legalising medical assistance in dying in Canada, was subsequently passed by the House of Commons and the Senate on 17 June 2016. As this remains a divisive issue for physicians, the Canadian Neurosurgical Society has recently published a position statement on MAID.MethodsWe conducted a cross-sectional survey to understand the views and perceptions among CNSS members regarding MAID to inform its position (...) statement on the issue. Data was collected from May to June 2016.ResultsOf the 300 active membes of the CNSS who recevied the survey, 89 respondents completed the survey, 71% of whom were attending neurosurgeons and 29% were neurosurgery residents. Most respondents,74.2%, supported the right of physicians to participate in MAID with 7.8% opposing. 37% had current patients in their practice fitting the criteria for MAID. 23.6% had been asked by patients to assist with MAID, but only 11% would consider personally providing it. 84% of neurosurgeons surveyed supported the physicians’ right to conscientious objection to MAID while 21% thought attending surgeons should be removed from the inquiry and decision-making process. 43.8% agreed that the requirment to refer a patient to a MAID service should be mandatory. Glioblastoma multiforme, quadriplegia/quadriparesis secondary to spinal tumour/trauma and Parkinson’s disease were the most common suggested potential indications for MAID among the neurosurgical population.ConclusionsOur results demonstrate that most neurosurgeons in Canada are generally supportive of MAID in select patients. However, they also strongly support the physicians’ right to conscientious objection. (shrink)

Examining one of the fundamental issues in cognitive psychology: How does our conscious experience come to be the way it is?

Already hailed as a masterpiece, Foundations of Language offers a brilliant overhaul of the last thirty-five years of research in generative linguistics and related fields. "Few books really deserve the cliché 'this should be read by every researcher in the field'," writes Steven Pinker, author of The Language Instinct, "but Ray Jackendoff's Foundations of Language does." Foundations of Language offers a radically new understanding of how language, the brain, and perception intermesh. The book renews the promise of early generative linguistics: (...) that language can be a valuable entrée into understanding the human mind and brain. The approach is remarkably interdisciplinary. Behind its innovations is Jackendoff's fundamental proposal that the creativity of language derives from multiple parallel generative systems linked by interface components. This shift in basic architecture makes possible a radical reconception of mental grammar and how it is learned. As a consequence, Jackendoff is able to reintegrate linguistics with philosophy of mind, cognitive and developmental psychology, evolutionary biology, neuroscience, and computational linguistics. Among the major topics treated are language processing, the relation of language to perception, the innateness of language, and the evolution of the language capacity, as well as more standard issues in linguistic theory such as the roles of syntax and the lexicon. In addition, Jackendoff offers a sophisticated theory of semantics that incorporates insights from philosophy of language, logic and formal semantics, lexical semantics of various stripes, cognitive grammar, psycholinguistic and neurolinguistic approaches, and the author's own conceptual semantics. (shrink)

Credences are beliefs about evidential probabilities. We give the view an assessment-sensitive formulation, show how it evades the standard objections, and give several arguments in support.

Understanding Hume’s theory of space and time requires suspending our own. When theorizing, we think of space as one huge array of locations, which external objects might or might not occupy. Time adds another dimension to this vast array. For Hume, in contrast, space is extension in general, where being extended is having parts arranged one right next to the other like the pearls on a necklace. Time is duration in general, where having duration is having parts occurring one aft (...) er another like the notes of a song. Hume’s diff erent view stems from his empiricism, his reliance on experience and observation as the foundation of our concepts. Nothing in our experience suggests a single vast array of locations. Rather, we simply notice that bodies are similar insofar as they have lengths that can be compared. Likewise, nothing in our experience suggests a single dimension of time. Rather, we simply notice that diff erent successions are similar insofar as they have durations that can be compared. Th eorizing that these observations show there to be a single multidimensional array goes well beyond the evidence for Hume. As a skeptic, he fi nds himself unable to assent to theories that stray too far beyond the deliverances of the senses. For Hume, the ideas of space and time are each a general idea of simple—partless— objects arrayed in a certain manner. He argues that the structures of the ideas of space and time refl ect the structures of space and time. Th erefore, space and time are not infi - nitely divisible, and they are ways simple objects are arrayed. Consequently, there is no such thing as empty space nor time without change. (shrink)

Semantic Structures is a large-scale study of conceptual structure and its lexical and syntactic expression in English that builds on the theory of Conceptual...

This book emphasizes the role of semantics as a bridge between the theory of language and the theories of other cognitive capacities such as visual perception...

The self‐proclaimed omnipotent rapscallion Q embodies some of the values celebrated by the great German philosopher Friedrich Wilhelm Nietzsche. Nietzsche is sometimes interpreted as someone who rejects all morals and values, a mistaken impression amplified by the title of one of his more famous books, Beyond Good and Evil. Nietzsche teaches that we must accept the past suffering that's gone into making us who we are. Q shares some of Nietzsche's outlook insofar as he, too, looks beyond social prescriptions about (...) safety and timidity that prevent us from developing the higher skills and powers through which we individuate ourselves. Though Q might think of himself as omniscient, he clearly doesn't know all details of the future, particularly the free actions that will be taken by Picard and others. Picard learns the lesson that there are many circumstances in which he might indeed need Q to save him and his crew. (shrink)

Discusses the scientific potential represented by intelligent machines and their social implications.

David Hume is famous as a sceptical philosopher but the nature of his scepticism is difficult to pin down. Hume's True Scepticism provides the first sustained interpretation of Part 4 of Book 1 of Hume's Treatise: his deepest engagement with sceptical arguments, in which he notes that, while reason shows that we ought not to believe the verdicts of reason or the senses, we do so nonetheless. Donald C. Ainslie addresses Hume's theory of representation; his criticisms of Locke, Descartes, (...) and other predecessors; his account of the imagination; his understanding of perceptions and sensory belief; and his bundle theory of the mind and his later rejection of it. (shrink)

Where much contemporary philosophy seeks to stave off the "threat" of nihilism by safeguarding the experience of meaning--characterized as the defining feature of human existence--from the Enlightenment logic of disenchantment, this book attempts to push nihilism to its ultimate conclusion by forging a link between revisionary naturalism in Anglo-American philosophy and anti-phenomenological realism in recent French philosophy. Contrary to an emerging "post-analytic" consensus which would bridge the analytic-continental divide by uniting Heidegger and Wittgenstein against the twin perils of scientism and (...) skepticism, this book short-circuits both traditions by plugging eliminative materialism directly into speculative realism. (shrink)